The precise role of 5-HT in the etiology of sexual dysfunction in men and women is uncertain. Indeed, it is the effects of orally administered drugs with actions on serotonergic function that afford what evidence there is. Accordingly, it is not yet clear whether disturbance of spinal or brain serotonergic neurotransmission is primarily responsible for the most frequent forms of sexual dysfunction seen in clinical practice with serotonergic drugs. The balance of the findings from animal experimentation would predict inhibitory effects on sexual function from drugs enhancing 5-HT neurotransmission.
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