H3c ch3

Structure 29

their antioxidative potential using human aortic endothelial cells (HAEC) to mediate oxidation of low-density lipoprotein (LDL) (Pearson et al., 1997). All anti-oxidants produced a dose-dependent inhibition of LDL oxidation. Most potent antioxidants in HAEC system were carnosic acid, carnosol and rosmarinic acid.

Some strong natural antioxidants like carnosol were proved to exhibit anti-inflammatory and inhibitory effects with regard to tumor-initiation activities in mice test systems (Huang et al., 1994). Also some sage compounds (ursolic and/or oleanolic acid) that show no antioxidant activity (Wu et al., 1982) may turn promising in future research of inflammation and of cancer prevention. A squalene derived triterpenoid ursolic acid (structure 29) and its isomer oleanolic acid (structure 30) (up to 4% in sage leaves, dry weight basis) (Brieskorn and Kapadia, 1980), act anti-inflammatory and inhibit tumorigenesis in mouse skin (Tokuda et al., 1986; Huang et al., 1994; Ho et al., 1994). Recent data on the anti-inflammatory activity of sage (S. officinalis L.) extracts when applied topically (IDJ0= 2040 pg/cm2) and evaluated as oedema inhibition after Croton oil—induced dermatitis in mouse ear, confirm/ suggest ursolic acid to be the main active ingredient, responsible for sage anti-inflammatory effect (Baricevic et al.,

0 0

Post a comment