Transformation of Salvianolic Acid A

Oxidative cyclization of salvianolic acid A in the presence of trace amount of acid yielded salvianolic acid C. A 20x20 cm TLC plate was impregnated with CHCl3-MeOH-HCOOH (85:15:2). After evaporation of the solvent 50 mg of salvianolic acid A was applied and the plate left for 48 h at room temperature. Multiple devel opment (x3) with CHCl3-MeOH-HCOOH (85:15:1) yielded a dark yellow fluorescent band and a bright green fluorescent band. Elution of the individual bands with acetone yielded 10 mg of salvianolic acid A and 20 mg of salvianolic acid C.

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