Irritant Reaction

ICD is the result of an unspecific damage due to contact to chemical substances that cause an inflammatory skin reaction [1-3, 5]. Exposure of human beings to irritants such as solvents, detergents and even water [18], at home and in work environments, leads to damage to the stratum corneum and hence skin barrier impairment [14]. The exact mechanisms of irritant action are incompletely understood, but it seems likely that there is an 'immunologic-like' component to the irritant response [3]. The clinical appearance of ICD varies depending on multiple external and internal factors [2, 3, 5]. Airborne ICD may develop in uncovered skin areas, mostly in the face and neck after exposure to volatile irritants or vapor. Avoidance of these irritants may not be practical for persons whose occupation or daily activities require them. Prophylactic measures reduce the risk of developing ICD: BCs and moisturizers may play a role in this strategy.

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