Excessive daytime sleepiness often occurs within 6 weeks of radiotherapy to the brain. It may be due to a direct effect of the radiotherapy, possibly acting through cytokines and other inflammatory mediators, but occasionally the symptoms may be due to a raised intracranial pressure due to worsening of the tumour for which the radiotherapy was given.
Excessive daytime sleepiness is common when a large volume of brain is irradiated, for instance with prophylactic treatment for leukaemia or small cell carcinomas of the bronchus, whereas localized radiotherapy even close to the hypothalamus for pituitary tumours causes less EDS. Excessive daytime sleepiness following cranial irradiation should be distinguished from the physical fatigue that follows radiotherapy to areas outside the brain.
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Salvation For The Sleep Deprived The Ultimate Guide To Sleeping, Napping, Resting And Restoring Your Energy. Of the many things that we do just instinctively and do not give much of a thought to, sleep is probably the most prominent one. Most of us sleep only because we have to. We sleep because we cannot stay awake all 24 hours in the day.