The normal diurnal rhythm of urinary output is abolished or even reversed in chronic renal disease, adrenal gland insufficiency and in the presence of oedema. This leads to nocturia which may also occur if there is bladder outflow obstruction, due, for instance, to prostatic hypertrophy, or with diuretic treatment.
The diurnal fluctuation in renal function may also be related to the tendency for episodes of gout to arise during sleep. Most of the uric acid which is produced by purine metabolism is excreted through the kidneys and a reduction in urate clearance at night may be responsible for hyperuricaemia.
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Salvation For The Sleep Deprived The Ultimate Guide To Sleeping, Napping, Resting And Restoring Your Energy. Of the many things that we do just instinctively and do not give much of a thought to, sleep is probably the most prominent one. Most of us sleep only because we have to. We sleep because we cannot stay awake all 24 hours in the day.