Programming of Neohepatocytes and Neoislets

In view of the urgent need for autologous cell replacement strategies in the treatment of diabetes or liver diseases and for drug testing/screening purposes, we focussed on the generation and functional evaluation of pancreatic islet and hepatocytes-like cells. We go on to show that these monocyte-derived "neo-islets" and "neo-hepatocytes" acquire highly specialized functions in vitro, otherwise only displayed by primary hepatocytes and islet cells, respectively. Moreover, we demonstrate that "neoheps" are able to repopulate critically resected liver organs and restore liver function in animals otherwise succumbing to acute liver failure.

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