Hsp Expression In The Arterial Intima

Berberian et al. (10) have shown high levels of hsp 70 in human atherosclerotic lesions, particularly in the central portions of atheroma and at necrotic core sites, correlating in intensity with the severity of the lesion. Hsp 70 was also demonstrated to increase arterial cell survival, suggesting that these proteins are associated with a protective mechanism in normal and diseased arteries (11). It is, however, not clear if hsp 70, like hsp 60, is involved in atherogenesis.

We studied hsp 60 expression in human atherosclerotic lesions with specimens of aortae, carotid arteries, and internal mammary arteries and veins as well

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