A spectrum of disease exists beginning with benign anogenital warts and ending with invasive epidermoid carcinoma. Somewhere in the transition from benign to malignant disease fits the giant condyloma acuminatum or Buschke-Lowenstein tumor. These terms generally refer to a low grade verrucous carcinoma which has
developed in a giant genital wart. Microscopically, the lesion appears benign but clinically it is locally aggressive. These lesions are often greater than 10 cm and may reach enormous size invading and destroying local tissues to include the anal sphincters, and into the pelvic cavity. Metastases are generally not reported.
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