Antiretroviral Drugs

ARV drugs belong to two main classes:

a) reverse transcriptase inhibitors (RTIs);

b) protease inhibitors (PIs).

RTIs are further divided into three groups:

i) nucleoside reverse transcriptase inhibitors (NsRTIs);

ii) non-nucleoside reverse transcriptase inhibitors (NNRTIs);

iii) nucleotide reverse transcriptase inhibitors (NtRTIs).

The table shows the ARV drugs (abbreviation in brackets) approved for inclusion in WHO's Model List of Essential Drugs (EDL) from April 2002.

NsRTIs NNRTIs PIs

Zidovudine (AZT, ZDV) Nevirapine (NVP) Saquinavir (SQV)

Didanosine (ddI) Efavirenz (EFV)

Ritonavir (RTV)

(as pharmacoenhancer)

Stavudine (d4T)

Indinavir (IDV)

Lamivudine (3TC)

Nelfinavir (NFV)

Abacavir (ABC)

Lopinavir/ritonavir (LPV/r)

Examples of other drugs not included in NsRTIs zalcitabine (ddC)

the EDL are give below:

NtRTI tenofovir (TDF)

NNRTIs delavirdine (DLV)

PIs amprenavir (APV)

Was this article helpful?

0 0

Post a comment