Children

The following table indicates the recommended doses of ARV drugs for children.

Name of drug

Formulations

Pharmacokinetic Age (weight), dose* data available 1 and dose frequency

Other comments

Nucleoside reverse transcriptase inhibitors (NsRTIs)

Capsules: 100 mg; 250 mg

Tablet: 300 mg

All ages

4 weeks to 1 3 years: 180 mg/m2 twice daily Maximum dose: > 1 3 yrs: 300 mg twice daily

Large volume of syrup not well tolerated in older children

Needs storage in glass jars and is light-sensitive

Can give with food

Doses of 600 mg/m2 twice daily required for HIV encephalopathy

Do not use with d4T (antagonistic antiretroviral effect)

Lamivudine (3TC)

Oral solution: 10 mg/ml

Tablet: 150 mg

All ages

Maximum dose: > 60 kg: 150 mg twice daily

Well tolerated

Can give with food

Store solution at room temperature (use within one month of opening)

Tablet can be washed, mixed with a small amount of water or food, and taken immediately

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