WHO recommends standardized and simplified ART regimens in support of effective large-scale ART programmes. Countries should select a single first-line, and a limited number of second-line, regimens for large-scale use. This clinical manual provides guidance on recommended first-line regimens. The WHO guidelines Scaling up antiretroviral therapy in resource-limited settings provide full details, including guidance on second-line regimens.The results of clinical studies and of surveillance for drug resistance should inform policies for recommended first-line and second-line regimens.
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