The outcome is fatal without treatment and often very poor with treatment. In many countries the drugs for treating cryptococcal meningitis are expensive, and are not often available in routine settings. The treatment for many patients is therefore symptomatic with analgesia and sedation. Patients who can afford specific antifungal drug treatment should receive fluconazole 400 mg daily initially for 10 weeks. Alternative regimens are i) intravenous amphotericin B (0.5 mg/kg per day) for 14 days followed by fluconazole 400 mg daily for 8 weeks or ii) intravenous amphotericin B (0.5 mg/kg per day) for 14 days followed by intraconazole 400 mg daily for 8 weeks. Lifelong maintenance treatment with fluconazole 200 mg daily is then necessary to prevent relapse.
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