Case definitions by site and result of sputum smear

Pulmonary TB - sputum smear-positive (PTB+)

Two or more initial sputum smear examinations positive for AFB or

1 sputum smear positive for AFB, and CXR abnormalities consistent with active pulmonary TB as determined by a clinician or

1 sputum smear positive for AFB, which is also culture positive for M. tuberculosis

Pulmonary TB - sputum smear-negative (PTB-)

A case of pulmonary TB that does not meet the above definition for smear-positive TB.

In keeping with good clinical and public health practices, diagnostic criteria should include:

at least three sputum smears negative for AFB and no response to a course of broad-spectrum antibiotics and

CXR abnormalities consistent with active TB and decision by a clinician to treat with a full course of anti-TB treatment Extrapulmonary TB

TB of organs other than the lungs: e.g. pleura, lymph nodes, abdomen, genitourinary tract, skin, joints, bones, meninges. Diagnosis is based on one culture-positive specimen, or histological or strong clinical evidence consistent with active extrapulmonary TB, followed by a decision by a clinician to treat with a full course of anti-TB treatment. A patient diagnosed with both pulmonary and extrapulmonary TB should be classified as a case of pulmonary TB.

The following are forms of extrapulmonary TB: pleural effusion (the pleurae are outside the lungs); miliary (TB is widespread throughout the body and not limited to the lungs).

8.1.4 Category of TB patient for registration on diagnosis New

A patient who has definitely never taken anti-TB drugs or who has taken anti-TB drugs for less than one month.

Relapse

A TB patient who:

a) previously received treatment and was declared cured or treatment completed;

and b) has once again developed bacteriologically positive (by smear or culture) TB.

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