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Fixed-dose combination of ZDV plus 3TC

No liquid available

Tablet: 300 mg ZDV plus 150 mg 3TC

Adolescents and adults

Maximum dose: > 1 3 years or > 60 kg: 1 tablet twice daily

Tablet should not be split

Tablet can be washed, mixed with a small amount of water or food, and taken immediately For children <30 kg, ZDV+3TC cannot be dosed accuately in tablet form

Didanosine (ddl, dideoxyinosine)

Oral suspension paediatric powder/ water: 10 mg/ml. In many countries needs to be made up with additional antacid

Chewable tablets: 25 mg; 50 mg; 100 mg; 150 mg; 200 mg

Enteric-coated beadlets in capsules: 125 mg; 200 mg; 250 mg; 400 mg

All ages

< 3 months: 50mg/m2 twice daily

3 months to 1 3 years: 90 mg/m2 twice daily or 240 mg/m2 once daily Maximum dose: > 1 3 years or > 60 kg: 200 mg twice daily or 400 mg once daily

Keeps suspension refrigerated; stable for 30 days; must shake well

Should be taken on an empty stomach, at least 30 minutes before or 2 hours after eating

Enteric-coated beadlets in capsules can be opened and sprinkled on small amount of food

Stavudine (d4T)

Oral solution: 1 mg/ml

Capsules: 15 mg, 20 mg, 30 mg, 40 mg

All ages

30 to 60 kg: 30 mg twice daily

Large volume of solution

Keep solution refrigerated; stable for 30 days; must shake well

TB/HIV:A CLINICAL MANUAL

Stavudine (d4T)

(continued)

Maximum dose: > 60 kg: 40 mg twice daily

Needs to be stored in glass bottles

Capsules opened up and mixed with small amount of food are well tolerated (stable in solution for 24 hours if kept refrigerated) Do not use with AZT (antagonistic antiretroviral effect)

Abacavir (ABC)

Oral solution: 20 mg/ml Tablet: 300 mg

Over age 3 months

Maximum dose: > 16 years or > 37.5 kg: 300 mg twice daily

Syrup well tolerated or can crush tablet

Can give with food

MUST WARN PARENTS ABOUT HYPERSENSITIVITY REACTION.

ABC should be stopped permanently if hypersensitivity reaction

Fixed-dose combination of ZDV plus 3TC plus ABC (trizavir)

No liquid available Tablet:

ZDV 300 mg plus 3TC 150 mg plus ABC 300 mg

Adolescents and adults

Maximum dose: > 40 kg: 1 tablet twice daily

Tablet cannot be split.

MUST WARN PARENTS ABOUT HYPERSENSITIVITY REACTION. Trizavir should be stopped permanently if hypersensitivity reaction

For children <30 kg, trizavir cannot be dosed accurately in tablet form

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