Health personnel should be aware of the special situations that influence the choice and dose of anti-TB drugs (see Chapter 9).
It is possible to prevent the peripheral neuropathy caused by isoniazid. This neuropathy usually shows as a burning sensation of the feet. It occurs more commonly in HIV-positive individuals and in people who drink alcohol. These patients should receive preventive treatment with pyridoxine 10 mg daily. Ideally, where possible, pyridoxine 10 mg daily should routinely accompany isoniazid.
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