Role of isoniazid preventive treatment in HIVpositive individuals

The theoretical benefits of IPT are attractive. The table shows the potential disadvantages and necessary precautions.

Potential disadvantage

Necessary precaution

risk of drug toxicity (especially liver damage)

do not give to people with chronic disease or who regularly drink excessive amounts of alcohol

emergence of drug resistance (if the patient has undetected TB disease and not just M. tuberculosis infection)

in all cases exclude TB disease by CXR, in patients with cough of 3 weeks' duration or more, do sputum microscopy

diversion of resources from NTP activities

funding must be from sources other than NTP (e.g.AIDS control programme, voluntary sector) or extra funding sources for the NTP must be found

Was this article helpful?

0 0

Post a comment