What are the recommended treatment doses of prednisolone

Rifampicin is a potent inducer of hepatic enzymes that metabolize steroids. The effective dose of prednisolone is therefore half the prescribed treatment dose given to the patient.The table below shows suggested treatment doses of prednisolone.

Indication Prednisolone treatment

(dose for children in brackets)

Indication Prednisolone treatment

(dose for children in brackets)

TB meningitis

60 mg (1-2 mg/kg) daily for weeks 1-4, then decrease over several weeks

TB pericarditis

60 mg (1-2 mg/kg) daily for weeks 1-4 30 mg (0.5-1 mg/kg) daily for weeks 5-8, then decrease over several weeks

TB pleural effusion

30 mg (0.5-1 mg/kg) daily for 1-2 weeks

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